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Oral changes in patients undergoing chemotherapy for breast cancer

Acharya, Shruthi and Pai, Keerthilatha M and Bhat, Sujatha and Mamatha, Ballal and Acharya, Shashidhar (2017) Oral changes in patients undergoing chemotherapy for breast cancer. Indian Journal of Dental Research, 28 (3). pp. 261-268. ISSN 0970-9290

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Abstract

Background: Breast cancer is one of the most common cancers in India. Most of the patients with breast cancer are treated with chemotherapy which has multiple oral complications. Aims: The objectives of this study were to describe the occurrence of taste disturbances, xerostomia, oral mucositis, oral pigmentation, and candidal and salivary changes among patients receiving chemotherapy for breast cancer. Methods: Fifty‑two women with newly diagnosed breast cancer (without distant metastasis), eligible for adjuvant/neoadjuvant chemotherapy (cyclophosphamide and adriamycin, 4 cycles × 3 weeks), were included in this study. All the observations were noted before, during (after 6 weeks of starting chemotherapy), and after the completion of chemotherapy (after 12 weeks of starting chemotherapy). Statistical Analysis Used: Variables such as mucositis, salivary flow rate, salivary pH, and candidal carriage rate were compared at baseline, and at 1st and 2nd follow‑ups using Wilcoxon signed‑rank test (P value corrected for α for pair‑wise comparisons). Results: Mean unstimulated whole salivary flow rate reduced from 0.5 ml/min to 0.3 ml/min, and the mean colony‑forming units of Candida reduced from 32.3 × 103 cells/ml to 13.1 × 103 cells/ml at the end of the study period. Xerostomia, taste disturbances, and oral mucosal pigmentation increased from 28.8% to 50%. Conclusions: There was a discernible change in oral mucosal, salivary, and candidal status during the course of the study.

Item Type: Article
Uncontrolled Keywords: Candidiasis; mucositis; oral pigmentation; salivary flow; salivary pH; taste disturbances; unstimulated whole saliva; xerostomia.
Subjects: Dentistry > MCODS Manipal > Preventive and Community Dentistry
Dentistry > MCODS Manipal > Oral Medicine and Radiology
Medicine > KMC Manipal > Microbiology
Depositing User: KMC Library
Date Deposited: 18 Jul 2017 09:02
Last Modified: 18 Jul 2017 09:02
URI: http://eprints.manipal.edu/id/eprint/149368

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