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Anticancer activity of stem bark extract and fractions of wrightia tinctoria in transplantable tumors in mice

Chaudhary, Shilpee and Setty, Manjunath M and Pai, Sreedhara Ranganath K (2017) Anticancer activity of stem bark extract and fractions of wrightia tinctoria in transplantable tumors in mice. Advanced Science Letters, 23 (3). pp. 1995-2000. ISSN 1936-6612

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Abstract

Wrightia tinctoria Roxb. (Apocynaceae), widely used in traditional medicine for inflammatory conditions and cancer, has not been studied extensively for its anticancer potential. The present study evaluated the anticancer activity of ethanol extract (EE) and petroleum ether (PE) and ethyl acetate (EA) fractions of stem bark of W. tinctoria using in vivo models. The anticancer activity was evaluated in Dalton’s lymphoma ascites (DLA) solid tumor and Ehrlich’s ascites carcinoma (EAC) liquid tumor models after treatment for 18 and 13 days respectively at 50 and 100 mg/kg i.p. EA at 100 mg/kg was most effective in DLA model with 71.1% inhibition in tumor volume. In EAC model, EA significantly inhibited body weight gain due to liquid tumor (p < 0.05). The mean survival time (MST) increased (p < 0.001) at both doses along with significant improvement in hematological, and antioxidant parameters. W. tinctoria possesses significant anticancer activity and further investigations are in progress to identify the phytochemical and mechanistic basis of action.

Item Type: Article
Uncontrolled Keywords: Wringhtia tinctoria; anticancer; solid Tumor; apocynaceae.
Subjects: Pharmacy > MCOPS Manipal > Pharmacognosy
Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 31 Jul 2017 03:56
Last Modified: 31 Jul 2017 03:56
URI: http://eprints.manipal.edu/id/eprint/149441

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