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Poly(N-vinyl-2-pyrrolidone-maleic anhydridestyrene) grafted terpolymer: Synthesis, characterization, and bactericidal property evaluation against E. coli and S. epidermidis

Ajithkumar, M P and Yashoda, M P and Prasannakumar, S and Sruth, T. V and Kumar, Sameer V. B. (2017) Poly(N-vinyl-2-pyrrolidone-maleic anhydridestyrene) grafted terpolymer: Synthesis, characterization, and bactericidal property evaluation against E. coli and S. epidermidis. Journal of Macromolecular Science Part A : Pure and applied Chemistry, 54 (07). pp. 480-488. ISSN 1060-1325

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Abstract

Poly(N-vinyl-2-pyrrolidone-maleic anhydride-styrene) terpolymer was prepared using AIBN initiator with acetone as solvent. The terpolymer was grafted with anti-bacterial agents para-aminobenzoic acid and 2,4-dichlorophenol to introduce bactericidal activity to the terpolymer. The terpolymer and the grafted polymers were characterized by FTIR, 1H-NMR, and 13C-NMR spectroscopic methods. Thermal properties were determined by differential scanning calorimetric technique and thermogravimetric analysis. The glass transition temperature was found to be 111�C (terpolymer), 150�C (VMS-G-PABA) and 130�C (VMS-GDCP). Terpolymer starts degradation at 288�C and grafted terpolymers at 104�C (VMS-G-PABA) and 129�C (VMS-G-DCP), respectively. The anti-bacterial activity of grafted terpolymers were evaluated by the shake flask method against gram positive and gram negative bacteria E. coli and S. epidermidis. The grafted terpolymers showed effective inhibition against both the bacteria, the minimum inhibition concentration was observed to be 75 mg/mL and 80 mg/mL for VMS-G-PABA and 50 mg/mL for VMS-G-DCP against E. coli and S. epidermidis, respectively. The new polymers showed 90% bacterial growth inhibition at 200 mg/mL.

Item Type: Article
Uncontrolled Keywords: 2,4-Diclorophenol; bactericidal activity; paraaminobenzoic acid; polymer synthesis; terpolymer grafting
Subjects: Engineering > MIT Manipal > Chemistry
Depositing User: MIT Library
Date Deposited: 03 Aug 2017 08:36
Last Modified: 03 Aug 2017 08:36
URI: http://eprints.manipal.edu/id/eprint/149466

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