Risk of GERD with diabetes mellitus, hypertension and bronchial asthma – a hospital based retrospective cohort study

Nandyal, Sitara and Suria, Sweta and Chogtu, Bharti and Bhattacharjee, Dipanjan (2017) Risk of GERD with diabetes mellitus, hypertension and bronchial asthma – a hospital based retrospective cohort study. Journal of Clinical and Diagnostic Research, 11 (7). OC25-OC29. ISSN 0973-709X

[img] PDF
00002995.pdf - Published Version
Restricted to Registered users only

Download (85kB) | Request a copy


Introduction: The rise in Gastro-Esophageal Reflux Disease (GERD) prevalence appears to have coincided with a simultaneous increase in the prevalence of diabetes mellitus, hypertension and bronchial asthma amongst the Indian population. Despite being evaluated extensively for their role as a risk factor for GERD, till date this relationship has remained a debatable one. Moreover, literature available on such studies conducted within Indian population remains scarce. Aim: The aim of the present study was to examine the risk of developing GERD in patients suffering from diabetes mellitus, hypertension and asthma in a Southern Indian population.The present retrospective, triple cohort and hospital based study was conducted by accessing the patient records from the medical records department of a tertiary care hospital in Southern India. Materials and Methods: The patient’s records were accessed from the year 2011 onwards. Relative Risk (RR) was calculated to determine the risk of development of GERD with every disease. Chi-square test was used to determine the statistical significance of the relationship between each disease and the development of GERD. A p-value of <0.05 was considered statistically significant. Results: In view of the time constraints as well as the limitations of the inclusion and exclusion criteria, data pertaining to only 40, 71 and 53 patients in Cohort 1 (diabetics), 2 (hypertensives) and 3 (bronchial asthmatics) respectively could be analyzed in the present study. The relative risk of GERD development was greater than 1 for patients belonging to Cohort 2 and 3, suggesting that the risk of GERD development is higher amongst hypertensives and asthmatics. Surprisingly, the diabetics (Cohort 1) were not associated with a high risk of GERD development. However, the relationship between any of the disease and GERD development was not statistically significant. Conclusion: The present study found an increased risk of GERD development amongst patients suffering from hypertension and bronchial asthma, but not with diabetes mellitus.

Item Type: Article
Uncontrolled Keywords: Gastro-esophageal reflux; Lifestyle diseases; Risk factors.
Subjects: Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 12 Aug 2017 04:26
Last Modified: 12 Aug 2017 04:26
URI: http://eprints.manipal.edu/id/eprint/149494

Actions (login required)

View Item View Item