Exploring the potential of laser capture microdissection technology in integrated oral biosciences

Thennavan, Aatish and Chandrashekar, Chetana and Radhakrishnan, Raghu (2017) Exploring the potential of laser capture microdissection technology in integrated oral biosciences. Oral Diseases, 23 (6). pp. 737-748. ISSN 1354-523X

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Abstract

Laser capture microdissection (LCM) is a high-end research and diagnostic technology that helps in obtaining pure cell populations for the purpose of cell- or lesion-specific genomic and proteomic analysis. Literature search on the application of LCM in oral tissues was made through PubMed. There is ample evidence to substantiate the utility of LCM in understanding the underlying molecular mechanism involving an array of oral physiological and pathological processes, including odontogenesis, taste perception, eruptive tooth movement, oral microbes, and cancers of the mouth and jaw tumors. This review is aimed at exploring the potential application of LCM in oral tissues as a high-throughput tool for integrated oral sciences. The indispensable application of LCM in the construction of lesion-specific genomic libraries with emphasis on some of the novel molecular markers thus discovered is also highlighted.

Item Type: Article
Uncontrolled Keywords: Laser capture microdissection; oral squamous cell carcinoma; oral embryology; oral physiology.
Subjects: Dentistry > MCODS Manipal > Oral Pathology and Microbiology
Depositing User: KMC Library
Date Deposited: 24 Aug 2017 11:00
Last Modified: 24 Aug 2017 11:00
URI: http://eprints.manipal.edu/id/eprint/149577

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