Extrapyramidal symptoms probably related to risperidone treatment: A case series

Thomson, Sereen Rose and Chogtu, Bharti and Bhattacharjee, Dipanjan and Agarwal, Saurabh (2017) Extrapyramidal symptoms probably related to risperidone treatment: A case series. Annals of Neurosciences, 24 (3). pp. 155-163. ISSN 0972-7531

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Abstract

Background: Atypical antipsychotics, like risperidone pur-portedly, score over their typical counterparts in terms of their lower propensity toward producing extrapyramidal symptoms (EPS). However, recent studies have furnished ev-idence to the contrary. Hereby, we present a case series im-plicating risperidone as the causative agent for EPS. Methtods: As a part of the pharmacovigilance programme of India, the authors have assessed 10 physician-reported cases of EPS among the 1,830 patients who were prescribed risperi-done within the time period of January 2012–December 2014 in a tertiary care hospital in South India. Causality, se-verity, and preventability assessments of adverse reaction were done as per Naranjo’s, Hartwig’s, and Thornton’scale respectively. Results: Of the 10 cases, a dose-dependent oc-currence of EPS was noted in all and the time duration for development of EPS ranged from 1 week to 2 years. Four pa-tients developed EPS at a dose of 6–8 mg, 4 developed at a dose of 4–6 mg, and the remaining 2 developed at 2 and 1 mg. Conclusion: A strong temporal correlation between risperidone and EPS was noted in all cases. High doses pro-duced EPS early, whereas moderate to low doses produced EPS at a later date. Thus, cautious use and close monitoring are warranted in the chronic use of risperidone.

Item Type: Article
Uncontrolled Keywords: Atypical antipsychotic; anticholinergic; bipolar disorder; cog wheel rigidity.
Subjects: Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 05 Sep 2017 04:19
Last Modified: 05 Sep 2017 04:19
URI: http://eprints.manipal.edu/id/eprint/149631

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