A diffusion tensor imaging study to sstimate normative fractional anisotropy values in different age groups of normal brain white matter

Kotian, Rahul P and Prakashini, K and Nair, Sreekumaran N and Babu, Satish M (2017) A diffusion tensor imaging study to sstimate normative fractional anisotropy values in different age groups of normal brain white matter. International Journal of Control Theory and Applications, 10 (36). pp. 195-204. ISSN 0974-5572

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Abstract

Background and purpose: DTI is one of the most sophisticated and relatively new neuroimaging technique that allows in vivo quantification of water diffusion properties. It can also assess the integrity of white matter microstructure. In our study, we investigated normative data from a large number of healthy participants in three different age groups to examine the developmental trends in diffusion tensor imaging during this white matter maturation period. Title: A Diffusion tensor imaging study to estimate normative Fractional anisotropy values in different age groups of normal brain white matter. Materials and Methods: DTI data in 85 healthy subjects in three different age groups were analyzed retrospectively using 1.5 T MRI system. FA values were measured at the corpus callosum, centrum semiovale and pons using fixed ROI technique with a b-value of 1000 s/mm2 and TE = 100 millisecond. Results: FA values showed regional variation between different white matter regions of the brain namely the corpus callosum, centrum semiovale and pons. The highest and lowest values found varied with each region studied in the brain white matter. Conclusions: In a normal adult population FA values of the brain white matter showed regional variation. These points should be taken into consideration while interpretation in clinical patients. We demonstrate a relationship between FA and normal ageing which is a key feature to detect early white matter changes. We propose that FA may provide an early means for the detection of age-related change and suggest a need for elaborate data to explore this association with comparison with a diseased population.

Item Type: Article
Uncontrolled Keywords: FA; fractional anisotropy; DTI; diffusion tensor imaging; b-value; TE; echo time; ms; milli second; MRI; diffusion imaging.
Subjects: Allied Health > MCOAHS Manipal > Medical Imaging Tech
Departments at MU > Statistics
Medicine > KMC Manipal > Radiology
Depositing User: KMC Library
Date Deposited: 23 Sep 2017 11:02
Last Modified: 23 Sep 2017 11:02
URI: http://eprints.manipal.edu/id/eprint/149735

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