Effect of phytoestrogenic constituents of fenugreek in comparison with synthetic estradiol on menopause induced hematological alterations

Jagadeesh, Akshay T and Anjaneyulu, K and Bhat, Kumar MR (2017) Effect of phytoestrogenic constituents of fenugreek in comparison with synthetic estradiol on menopause induced hematological alterations. Advanced Science Letters, 23. pp. 1990-1994. ISSN 1936-6612

[img] PDF
Research Article 1.pdf - Published Version
Restricted to Registered users only

Download (1MB) | Request a copy

Abstract

At menopause the physiological parameters modulated by estrogen are disrupted leading to various symptoms. Hormone replacement therapy though beneficial has its own drawbacks. Fenugreek seeds, commonly used in Indian households, is known to possess phytoestrogens. Considering the lack of literature in support of this, this study was conducted to compare the effects of fenugreek seed extract and 17�-estradiol on menopause induced alterations in hematological parameters, employing the ovariectomised rat model. Female Wistar rats, 8 months old were randomly assigned into 4 groups (n = 6): (1) normal control, (2) ovariectomised and untreated, (3) ovariectomised and treated orally with fenugreek seed extract, (4) ovariectomised and treated with subcutaneous injections of estradiol. Post-treatment blood samples were collected and various hematological parameters were analyzed. Fenugreek treated rats showed higher hemoglobin, hematocrit and RBC counts in comparison to ovariectomised group. Additionally, they showed a higher total leukocyte count (TLC), specifically a higher lymphocyte count than that of control. Estradiol treated groups showed severe leukopenia owing to lymphocytopenia; decreased RBC counts, hemoglobin and hematocrit. However, the changes were statistically significantly only with estradiol treatment. Overall, fenugreek was found to be a better agent to attenuate the menopause induced hematological alterations.

Item Type: Article
Uncontrolled Keywords: Trigonella Foenum Graecum; Fenugreek; Ovariectomised; Hematology.
Subjects: Medicine > KMC Manipal > Anatomy
Depositing User: KMC Library
Date Deposited: 26 Sep 2017 04:31
Last Modified: 26 Sep 2017 04:31
URI: http://eprints.manipal.edu/id/eprint/149740

Actions (login required)

View Item View Item