Simultaneous determination of linezolid and levamisole hydrochloride in a fixed dose combination

Kumar, Lalit and Singh, Yugvijay Yadav and Rathnanand, Mahalaxmi (2017) Simultaneous determination of linezolid and levamisole hydrochloride in a fixed dose combination. Indian Journal of Pharmaceutical Education and Research, 51 (4). pp. 613-619. ISSN 0019-5464

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Abstract

Background: The combination of antibiotics with an immune-stimulant can be used for the prevention of antimicrobial resistance. Multilayer tablets of linezolid and levamisole hydrochloride can be a solution of this problem. Objective: Aim of the present study was to High Performance Liquid Chromatography method development and validation as per the International Council for Harmonisation guidelines for analysis of both the drugs simultaneously in a single unit dosage form. Methods: Ammonium acetate and acetonitrile in the ratio 65:35 (%v/v) was used as mobile phase. Ultra violet detection was carried out at 236 nm and flow rate was kept as 0.9 mL/min. Results: Linezolid and levamisole hydrochloride were found at 4.61 min and 6.45 min retention times, respectively. Conclusion: The study confirmed that the present method can be used for routine simultaneous analysis of linezolid and levamisole hydrochloride.

Item Type: Article
Uncontrolled Keywords: HPLC, Levamisole hydrochloride, Linezolid, Antibacterial resistance, Antimicrobial resistance.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Library
Date Deposited: 06 Oct 2017 11:18
Last Modified: 06 Oct 2017 11:18
URI: http://eprints.manipal.edu/id/eprint/149760

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