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Photosensitive Surfactants with Various Hydrophobic Tail Lengths for the Photocontrol of Genomic DNA Conformation with Improved Efficiency

Diguet, Antoine and Naresh, K Mani and Geoffroy, Marie and Sollogoub, Matthieu and Baigl, Damien (2010) Photosensitive Surfactants with Various Hydrophobic Tail Lengths for the Photocontrol of Genomic DNA Conformation with Improved Efficiency. Chemistry A European Journal, 16. pp. 11890-11896.

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Abstract

We report the synthesis and characterisation of photosensitive cationic surfactants with various hydrophobic tail lengths. These molecules, called AzoCx, are used as photosensitive nucleic acid binders (pNABs) and are applied to the photocontrol of DNA conformation. All these molecules induce DNA compaction in a photodependent way, originating in the photodependent polarity of their hydrophobic tails. We show that increasing hydrophobicity strongly enhances the compaction efficiencies of these molecules, but reduces the possibility of reversible photocontrol of a DNA conformation. Optimal performance was achieved with AzoC5, which allowed reversible control of DNA conformation with light at a concentration seven times smaller than previously reported.

Item Type: Article
Uncontrolled Keywords: azo compounds · DNA · hydrophobic interactions · photocontrol · surfactants
Subjects: Engineering > MIT Manipal > Biotechnology
Depositing User: MIT Library
Date Deposited: 31 Oct 2017 09:54
Last Modified: 31 Oct 2017 09:54
URI: http://eprints.manipal.edu/id/eprint/149892

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