Clinical use of fresh frozen plasma in a tertiary care hospital from India

Raturi, Manish and Shastry, Shamee and Murugesan, Mohandoss and Baliga, Poornima (2017) Clinical use of fresh frozen plasma in a tertiary care hospital from India. Journal of Transfusion Medicine, 10 (3). pp. 77-83. ISSN 1689–6017

[img] PDF
00003351.pdf - Published Version
Restricted to Registered users only

Download (242kB) | Request a copy


Background. Increased utilization of fresh frozen plasma (FFP) over the last decade has caused a rising trend in its unjustified usage exposing recipients to both infectious and non- -infectious hazards. The aim of the study was to observe the pattern of clinical use of plasma at a tertiary care hospital from India. Material and methods. Prospective analysis of all the requests raised for plasma was carried out. Indicators namely homogeneity of the requisition forms, patient demographics, indications for transfusion, dosage, pre-transfusion coagulation parameters and adverse events were noted. Appropriateness was defined based on compliance to both national and international standards. Data was analyzed using SPSS version 20 (IBM, USA). Results. Total nine hundred ninety eight patients (Males: 66%) received 4991 units of plasma at an average of two episodes per patient. Majority were adults 83.6% (n = 835). Primary users were internal medicine (32%) and plastic surgery (17%) respectively. Most common indication was bleeding with coagulopathy seen in 41% (411/998) patients. Average plasma volume administered was 456.2 ± 287.4 (17 to 2800) mL per episode. Pre- -transfusions INR value was available in only 63.2% (n = 1317) episodes. Overall, 56% (n = 1169) episodes were deemed appropriate. Total 0.28% plasma related adverse reactions were seen and reported to the national hemovigilance database. Mortality in the study group was 7.2%. Conclusion. Existing transfusion practices for plasma use were moderately compliant with the standards. Commonest indications for inappropriate FFP use were for low protein states and prophylaxis without any evidence of bleeding.

Item Type: Article
Uncontrolled Keywords: Fresh frozen plasma; appropriateness; clinical usage; guidelines.
Subjects: Medicine > KMC Manipal > Immunohematology and Blood Transfusion
Depositing User: KMC Library
Date Deposited: 31 Oct 2017 06:00
Last Modified: 31 Oct 2017 06:00

Actions (login required)

View Item View Item