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Acute anti-inflammatory activity of Pandanus fasicularis Lam

*, Raveendra Kumar N and *, Sanjeeva and *, Padmalaxmi D and *, Ananthababu and *, Udupa AL and Gupta, Subir and *, Nkemcho Ojeh and *, Rathnakar U P and Patil, Vijayalaxmi and Rao, Sanjana and *, Nisarga S and *, Shubha HV and Benegal, Deepa and Benegal, Adarsha and *, Prabhath Kodancha G (2011) Acute anti-inflammatory activity of Pandanus fasicularis Lam. Journal of Pharmacy Research, 4 (4). pp. 1234-1236.

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Abstract

Plants are widely used in the various traditional system of medicine like Ayurveda, Siddha, and Unani for their analgesic, and anti-inflammatory, antipyretic activity. Pandanus fascicularis Lam. (Synonyms-Pandanus tectorius, Pandanus odoratissimus, family–Pandanaceae) has been used in rheumatic fever, rheumatism and rheumatoid arthritis. The principle constituent is the Kewda oil, isolated from the inflorescences of Pandanus fascicularis. The chemical composition of this essential oil, obtained by hydrodistillation of staminate inflorescences of Kewda (Pandanus fascicularis) include more than sixty components. The major components of the hydrodistillated Kewda oil are 2-phenyl ethyl methyl ether terpene-4-ol, a –terpeniol and 2- phenyl ethyl alcohol benzyl benzoate etc. Kewda oil is traditionally used in ear ache, head ache, arthritis, debility, giddiness, laxative, rheumatism. After initial phytochemical screening of methanolic (MEPF) and aqueous extracts(AEPF) of the plant, the extracts were screened for possible acute anti-inflammatory properties in vivo models. Acute anti-inflammatory properties of both the extracts were tested in rodent models by carrageenan induced paw edema, albumin induced plantar edema, acetic acid induced vascular permeability and castor induced diarrhoea. In all these animal models MEPF and AEPF have shown significant anti-inflammatory activity.

Item Type: Article
Uncontrolled Keywords: Pandanus fascicularis, acute inflammation, Carrageenan, castor oil induced diarrhoea, rodents, vascular permeability
Subjects: Medicine > KMC Mangalore > Pharmacology
Depositing User: KMCMLR User
Date Deposited: 13 Oct 2011 11:08
Last Modified: 18 Oct 2011 06:42
URI: http://eprints.manipal.edu/id/eprint/1499

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