Generation of an induced pluripotent stem cell line fromchorionic villi of a Turner syndrome spontaneous abortion

Parveen, Shagufta (2017) Generation of an induced pluripotent stem cell line fromchorionic villi of a Turner syndrome spontaneous abortion. Stem Cell Research, 19. pp. 12-16. ISSN 1873-5061

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Abstract

A major cause of spontaneous abortions is chromosomal abnormality of foetal cells.We report the generation of an induced pluripotent stem cell line from the fibroblasts isolated from chorionic villi of an early spontaneously aborted foetuswith Turner syndrome. The Turner syndrome villus induced pluripotent stemcell line is transgene free, retains the original XO karyotype, expresses pluripotency markers and undergoes trilineage differentiation. This pluripotent stem cell model of Turner syndrome should serve as a tool to study the developmental abnormalities of foetus and placenta that lead to early embryo lethality and profound symptoms like infertility in 45 XO survivors.

Item Type: Article
Uncontrolled Keywords: Chromosomal abnormality ; Early embryo lethality ; 45 XO embryos ; Pluripotent stem cell model of Turner ; syndrome .
Subjects: Regenerative Medicine > MIRM Bangalore
Depositing User: MCON Library
Date Deposited: 10 Nov 2017 09:06
Last Modified: 10 Nov 2017 09:06
URI: http://eprints.manipal.edu/id/eprint/149930

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