Experimental data of co-crystals of Etravirine and L-tartaric acid

Pai, Aravinda and Muddukrishna, BS (2018) Experimental data of co-crystals of Etravirine and L-tartaric acid. Data in Brief, 16. pp. 135-140. ISSN 2352-3409

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Abstract

Etravirine is a drug used alongside other medication in the treatment of HIV and is a non-nucleoside reverse transcriptase inhibitor. It is a BCS class IV drug, having low solubility and high permeability (Drugbank, https://www.drugbank.ca/drugs/ DB06414) [1]. As a result, large doses of the drug are required for treatment. Two pills have to be taken twice a day, making it a “pill burden” (Intelencehttp://www.intelence.com/hcp/dosing/admin istration-options) [2]. Therefore, attempts of co-crystallizing Etravirine are attractive as the solubility of the drug tends to increase in this solid form (Schultheiss and Newman, 2009) [3]. In this study Etravirine co-crystals were synthesized in the molar ratios 1:1, 1:2 and 2:1 with L-tartaric acid as the co-former. Both slow evaporation and physical mixture was performed to mix the components. DSC values of final products are presented as well as FTIR spectra to observe the altered intermolecular interactions. A chemical stability test was performed after seven days using area under curve data from an HPLC instrument.

Item Type: Article
Uncontrolled Keywords: Etravirine ; Co-crystals ; HPLC ; FTIR instrument ; DSC instrument.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Pharmacy > MCOPS Manipal > Pharmaceutical Quality Assurance
Depositing User: KMC Library
Date Deposited: 21 Nov 2017 09:21
Last Modified: 21 Nov 2017 09:21
URI: http://eprints.manipal.edu/id/eprint/150000

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