Optimization of Chitosan Nanoparticles Synthesis and Its Applications in FattyAcid Absorption

Raval, Ritu and Rangnekar, Raj H and Raval, Keyur (2017) Optimization of Chitosan Nanoparticles Synthesis and Its Applications in FattyAcid Absorption. In: Materials, Energy and Environment Engineering. Spirnger.

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Chitosan is a linear polysaccharide composed of b-(1-4)-linked D-glucosamine and N-acetyl-D-glucosamine. It is obtained commercially by chemically treating the chitin obtained from shrimp and other crustacean shells with the alkali; sodium hydroxide (Austin et al. 1981). Owing to the cationic polyamines present on the chitosan, it has many commercial and biomedical applications. The ability of the biopolymer to limit fat absorption has been exploited in the present research. The studies have involved the hypercholesterolemic mice model treated with chitosan varying in degree of polymerization (DP) and acetylation (DA) (Baker et al. 2009; Patti et al. 2015; Stefan et al. 2014; Sugano et al. 1988; Zhang et al. 2008). The usage of chitosan in fat scavenging has also been extended to human patients. The bottleneck in the fat absorption has been the linear morphology of chitosan. This manuscript addresses and improvises on this limitation by making nanoparticles of chitosan. The spherical morphology of the nanoparticle would improve the surface area and thus the ability to absorb fats. In making these nanoparticles, the Ionotrophic gelation method is used. This method makes use of the electrostatic interaction between the amine group of chitosan (dissolved in the organic acid) and R. Raval _ R.H. Rangnekar

Item Type: Book Section
Uncontrolled Keywords: chitosan, nanoparticles
Subjects: Engineering > MIT Manipal > Biotechnology
Depositing User: MIT Library
Date Deposited: 28 Nov 2017 04:55
Last Modified: 28 Nov 2017 04:55
URI: http://eprints.manipal.edu/id/eprint/150080

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