Comparison of midazolam with fentanyl‑midazolam combination during flexible bronchoscopy: A randomized, double‑blind, placebo‑controlled study

Prabhudev, Amithash Marulaiah and Chogtu, Bharti and Magazine, Rahul (2017) Comparison of midazolam with fentanyl‑midazolam combination during flexible bronchoscopy: A randomized, double‑blind, placebo‑controlled study. Indian Journal of Pharmacology, 49 (4). pp. 304-311. ISSN 0253-7613

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Abstract

BACKGROUND: Sedation during flexible bronchoscopy is desirable, but the drugs and the dosage protocols that are used vary. OBJECTIVE: To study and compare the effects of midazolam with fentanyl‑midazolam combination during flexible bronchoscopy. MATERIALS AND METHODS: The study was conducted on 144 patients, from October 2013 to July 2015. They answered Hospital Anxiety and Depression Scale‑Anxiety subscale and a prebronchoscopy questionnaire to assess their expectation toward flexible bronchoscopy. The patients were randomized into three groups: placebo, midazolam, and fentanyl‑midazolam. Vitals signs including heart rate, respiratory rate, blood pressure, and oxygen saturation (SpO2) were recorded. Furthermore, Ramsay Sedation Scale was assessed during the procedure. Primary outcome measure was the composite score of patient‑reported tolerance and satisfaction (assessed after the procedure). Secondary outcome measures were composite score of physician‑reported feasibility of the procedure, hemodynamic changes during bronchoscopy, and side effects. RESULTS: Patient‑reported tolerance and satisfaction composite scores (median, interquartile range) for placebo, midazolam, and fentanyl‑midazolam groups were 54 (52, 57), 59 (57, 61.5), 62 (58.5, 66), respectively; P < 0.001. Physician‑reported feasibility composite scores (median, interquartile range) for the respective groups were 24.5 (20.5, 28), 25 (21, 27), 26 (25, 29); P = 0.004. There was no significant difference between the groups so far as mean heart rate (P = 0.305), mean systolic blood pressure (P = 0.532), mean diastolic blood pressure (P = 0.516), mean respiratory rate (P = 0.131), and mean SpO2 (P = 0.968) were concerned. CONCLUSION: Conscious sedation with fentanyl and midazolam combination can result in better patient and operator satisfaction when compared with midazolam alone.

Item Type: Article
Uncontrolled Keywords: Fentanyl; flexible bronchoscopy; midazolam.
Subjects: Medicine > KMC Manipal > Pharmacology
Medicine > KMC Manipal > Pulmonary Medicine
Depositing User: KMC Library
Date Deposited: 22 Dec 2017 04:09
Last Modified: 22 Dec 2017 04:09
URI: http://eprints.manipal.edu/id/eprint/150331

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