Influenza B Virus Triggering Macrophage Activation Syndrome in an Infant

*, Jayashree K and Rao, Suchetha and Kamath, Nutan (2017) Influenza B Virus Triggering Macrophage Activation Syndrome in an Infant. Indian Journal of Critical Care Medicine, 21 (11). pp. 802-803. ISSN 0972-5229

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Abstract

Macrophage activation syndrome (MAS) is a potentially fatal complication caused by excessive activation and expansion of macrophages and T lymphocytes. It can be triggered by various infections and is characterized by the development of cytopenias, hyperferritinemia, liver dysfunction, and coagulopathy. We report a 10‑month‑old female infant with fever, convulsions, and hepatosplenomegaly. Laboratory data of bicytopenia, low erythrocyte sedimentation rate, and elevated liver enzymes suggested MAS. This was supported by the presence of hyperferritinemia with hypertriglyceridemia. MAS was triggered by influenza B virus. She responded to treatment with immunoglobulin and steroid.

Item Type: Article
Uncontrolled Keywords: Bicytopenia, hyperferritinemia, hypertriglyceridemia, secondary hemophagocytic lymphohistiocytosis, thrombocytopenia
Subjects: Medicine > KMC Mangalore > Paediatrics
Depositing User: KMCMLR User
Date Deposited: 22 Dec 2017 05:47
Last Modified: 22 Dec 2017 05:47
URI: http://eprints.manipal.edu/id/eprint/150337

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