Phagosome-lysosome Fusion Hijack - An Art of Intracellular Pathogens

Shrivastava, Rohini and Pradhan, Gourango and Singh, Parul (2017) Phagosome-lysosome Fusion Hijack - An Art of Intracellular Pathogens. Proceedings of the Indian National Science Academy, 83 (3). pp. 533-548. ISSN 0370-0046

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Abstract

Phagosome-lysosome fusion is an important innate-effector immune response of host macrophages. After entering the macrophages through phagocytosis, intracellular bacteria and parasites reside inside the phagosomes. In many cases, these pathogens prevent maturation of hagosomes and its fusion with lysosomes. Several signaling cascades are shown to be associated with blocking of phagosome maturation process. Understanding the mechanism of phagosome-lysosome fusion and factors regulating this process, as well as the strategies adopted by the intracellular pathogens to prevent phagosomelysosome fusion might provide insights for the development of new drugs and more effective treatment options to combat infectious diseases

Item Type: Article
Uncontrolled Keywords: Phagosome-lysosome Fusion; Host Signaling; Cytokines; Rab GTPases; Lipid Bodies
Subjects: Research > Research Center - Health Sciences
Depositing User: KMC Library
Date Deposited: 28 Dec 2017 09:19
Last Modified: 28 Dec 2017 09:19
URI: http://eprints.manipal.edu/id/eprint/150367

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