Central Nervous System Fungal Infection and Acute Lymphoblastic Leukemia in Children: What is the Optimal Duration of Antifungal Therapy?

Lashkari, Harsha P. and Fernandes, Neil and Alva, Kishan and Rai, Santosh (2017) Central Nervous System Fungal Infection and Acute Lymphoblastic Leukemia in Children: What is the Optimal Duration of Antifungal Therapy? Journal of Pediatric Hematology Oncology, 39 (6). pp. 312-317. ISSN 10774114

[img] PDF
Journal of Pediatric Hematology Oncology.pdf - Published Version
Restricted to Registered users only

Download (191kB) | Request a copy

Abstract

Invasive fungal infections are rare in children with acute lymphoblastic leukemia. It compromises the antileukemia therapy should it happen. Central nervous system fungal infections carry high mortality. We here report the case of a 6.5-year-old girl who developed multiple central nervous system fungal abscesses possibly due to Aspergillus infection during induction therapy for acute lymphoblastic leukemia who has been successfully managed without compromising antileukemia therapy. She has been receiving antifungal therapy and maintenance chemotherapy for 20 months from diagnosis. We reviewed literature about the optimal duration of therapy for such children as the reported cases duration ranged between 4 and 24 months.

Item Type: Article
Uncontrolled Keywords: acute lymphoblastic leukemia, antifungal therapy, fungal brain abscesses, CNS fungal infection
Subjects: Medicine > KMC Mangalore > Paediatrics
Medicine > KMC Mangalore > Radio Diagnosis and Imaging
Depositing User: KMCMLR User
Date Deposited: 28 Dec 2017 06:27
Last Modified: 28 Dec 2017 06:27
URI: http://eprints.manipal.edu/id/eprint/150376

Actions (login required)

View Item View Item