Study of Serum Protein Gel Electrophoresis Pattern in Relation to Elevated Erythrocyte Sedimentation Rate

Shetty, Tanvi and Singh, Brij Mohan Kumar and Shetty, Panna P and Bishnu, Arijit (2018) Study of Serum Protein Gel Electrophoresis Pattern in Relation to Elevated Erythrocyte Sedimentation Rate. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 9 (1). pp. 657-662. ISSN 0975-8585

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Abstract

ESR is the most frequently used laboratory test in cases of acute phase or chronic inflammatory conditions. In these conditions, there are consequent changes noted in the serum protein fractions which are studied with the help of electrophoresis. It is seen that the ESR is greatly influenced by the extent to which the red cells form rouleaux. The rouleaux formation and red cell clumping are mainly controlled by the concentrations of fibrinogen and other acute phase proteins; e.g. haptoglobin, ceruloplasmin, alpha-1 antiglycoprotein, alpha-1 antitrypsin and C-reactive protein. Rouleaux formation is retarded by Albumin and accelerated by raised concentrations of serum Globulin or unusually altered Albumin:Globulin (A:G) ratio. This study is done in view of determining the electrophoretic changes occurring in serum protein levels in cases of elevated ESRs more than 30mm/ first hr

Item Type: Article
Uncontrolled Keywords: ESR; Get electrophoresis; Serum protein; Hemoglobin
Subjects: Medicine > MMMC Manipal > Pathology
Medicine > KMC Manipal > Pathology
Depositing User: KMC Library
Date Deposited: 29 Jan 2018 09:16
Last Modified: 29 Jan 2018 09:16
URI: http://eprints.manipal.edu/id/eprint/150489

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