Hansen’s Neuritis Revisited – A Clinicopathological Study

Jaiswal, Navya and Chakraborti, Shrijeet and Nayak, Kashinath and Pai, Shivananda and *, Shelley B. P. and *, Saraswathy Sreeram and *, Rakshith KC and *, Suresh BV and *, Misri Z K and Alva, Hansraj and *, Shankar N. (2018) Hansen’s Neuritis Revisited – A Clinicopathological Study. Journal of Neurosciences in Rural Practice, 9 (1). pp. 42-55. ISSN 0976-3147

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Introduction: Leprosy affecting the nerve solely or with concomitant skin lesions is not an uncommon condition in clinical practice. It is responsible for extensive morbidity and often poses a diagnostic challenge. This study aims to highlight the clinicopathological features of Hansen’s neuritis (HN). Materials and Methods: In this retrospective study, cases of histologically diagnosed HN, from January 2010 to July 2017, were reviewed in the light of clinical features, treatment history, and outcome. Results: There were 18 cases of HN which accounted for 3.97% of total nerve biopsy samples (n = 453) and 0.02% of total histopathology samples (n = 81,013). The male: female ratio was 5:1 in the cases of HN. Age range was 20–79 years with a mean age of 42.4 years (standard deviation: ±14.03). Among the HN cases, there were 13 cases of pure neuritic leprosy (61.1%). Mononeuritis multiplex was the most common finding in the nerve conduction study. Six (33.3%) cases exhibited histological features of borderline tuberculoid leprosy, followed by five (27.8%) cases of mid‑borderline features, three (16.7%) cases each of borderline lepromatous and burnt‑out HN, and one (5.6%) case of polar tuberculoid leprosy. Lepra bacilli were detected on Fite‑Faraco stain in 44.4% cases. Conclusion: Diagnosis of HN depends on astute search for skin lesions, nerve thickening or tenderness, sensory or motor symptoms, histopathological examination, and demonstration of lepra bacilli.

Item Type: Article
Uncontrolled Keywords: Hansen’s neuritis, lepra bacilli, mononeuritis multiplex, pure neuritic leprosy
Subjects: Medicine > KMC Mangalore > Pathology
Medicine > KMC Mangalore > Dermatology
Medicine > KMC Mangalore > Neurology
Depositing User: KMCMLR User
Date Deposited: 30 Jan 2018 11:07
Last Modified: 30 Jan 2018 11:07
URI: http://eprints.manipal.edu/id/eprint/150507

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