Prophylactic Choline Supplementation Attenuates Vascular Cognitive Impairment in Rodent Model of Ischemic Stroke

Sivakumar, G and Rajesh, T and Rao, Mohandas KG and Rai, Kiranmai S (2017) Prophylactic Choline Supplementation Attenuates Vascular Cognitive Impairment in Rodent Model of Ischemic Stroke. Indian Journal of Physiology and Pharmacology, 61 (3). pp. 246-255. ISSN 0019-5499

[img] PDF
4011 DisplayPdf.pdf - Published Version
Restricted to Registered users only

Download (76kB) | Request a copy

Abstract

Introduction: Stroke is the second leading cause of mortality in the world and estimated to be about 0.22% in India. Current management of post stroke vascular cognitive impairment (VCI) is not satisfactory. Choline is an important component of neuronal membrane phospholipids known to enhance cognition.Objective: To explore the prophylactic efficacy of choline in attenuating VCI in a rat model of ischemic brain injury. Materials and Methods: 10 month old male Wistar rats (n=8/group) were assigned as normal control,Bilateral common carotid artery occlusion (BCCAO), Sham BCCAO and Prophylactic BCCAO choline supplemented groups. Subsequently, all the groups of rats were subjected to cognitive function tests.Results: BCCAO rats showed significant deficits (p< 0.05) in cognitive functions compared to age matched sham BCCAO and NC rats. Prophylactic supplementation of choline in chronic cerebral hypoperfusion ischemic brain injured rats significantly restored learning and memory abilities (P<0.001) compared to age matched BCCAO rats.Conclusion: Prophylactic dietary choline supplementation attenuates vascular cognitive impairment in rodent model of ischemic stroke. Thus, after appropriate human clinical trials, dietary choline supplementation may be considered as a preventive strategy to attenuate post stroke cognitive impairment in high risk individuals.

Item Type: Article
Subjects: Medicine > MMMC Manipal > Anatomy
Medicine > MMMC Manipal > Physiology
Medicine > KMC Manipal > Physiology
Depositing User: KMC Library
Date Deposited: 21 Feb 2018 04:37
Last Modified: 21 Feb 2018 04:37
URI: http://eprints.manipal.edu/id/eprint/150619

Actions (login required)

View Item View Item