Effect of Simvastatin on Neuroinflammation in Microglial Cells Via Mitogen‑activated Protein Kinase and Nuclear Factor κB Pathways

Manokaran, K (2018) Effect of Simvastatin on Neuroinflammation in Microglial Cells Via Mitogen‑activated Protein Kinase and Nuclear Factor κB Pathways. Pharmacognosy Magazine, 1 (1). pp. 1-8. ISSN 0973-1296

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Abstract

Background: Activated microglial cells are found in different sorts of the neurodegenerative process including Parkinson and Alzheimer. Suppressing the activated microglial cells developed as a novel procedure for the treatment of neuroinflammation‑based neurodegeneration. Materials and Methods: We have investigated the effects of simvastatin on memory impairment and inflammatory cytokines expression induced by transient cerebral ischemia in cultured microglial cells. Results: The lipopolysaccharide (LPS)‑activated microglial cells treated with simvastatin 3 μmol has decreased the inflammation which was indicated by the reduced levels of the nitric oxide (NO), tumor necrosis factor‑α, interleukin‑1 β, cyclooxygenase‑2, and inducible NO synthase. Simvastatin also delayed the activation of atomic component nuclear factor‑κB, p38 mitogen‑activated protein kinase, and the reactive oxygen species in LPS‑activated microglial cells. Moreover, simvastatin has provoked the outflow of heme oxygenase‑1 in BV‑2 microglial cells. Conclusions: The present study showed that the simvastatin antagonizes neuroinflammation and can be a potential restorative operator for treating neuroinflammatory ailments.

Item Type: Article
Uncontrolled Keywords: Lipopolysaccharide; Microglial cells; Neuroinflammation; Simvastatin
Subjects: Allied Health > MCOAHS Manipal > Medical Laboratory Tech
Depositing User: KMC Library
Date Deposited: 06 Mar 2018 03:37
Last Modified: 06 Mar 2018 03:37
URI: http://eprints.manipal.edu/id/eprint/150682

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