Role of host cell factor-1 in cell cycle regulation

Zargar, Zaffer Ullah (2012) Role of host cell factor-1 in cell cycle regulation. Transcription, 3 (4). pp. 187-192.

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Abstract

Host cell factor-1(HCF-1) was first discovered as a cellular cofactor in the VP16-induced complex, a multi-protein DNA complex that forms on immediate early gene promoters of herpes simplex virus (HSV) to activate viral gene transcription. Subsequent research has revealed HCF-1 to be an abundant chromatin-associated protein that regulates various stages of the cell cycle. Recent reports show that HCF-1 interacts with diverse E2F proteins to induce cell-cycle-specific transcription. HCF-1 can act as a scaffold to a variety of histone-modifying proteins and these HCF-1-E2F-containing multi-protein complexes can bring about context-dependent activation or repression of transcription. In this review we examine the diversity of HCF-E2F interactions and the variety of multi-protein complexes it occurs in, to influence the local chromatin landscape at the E2F-promoters.

Item Type: Article
Uncontrolled Keywords: Transcription; histone modification; H3K4 HMT; HCF-1; E2F.
Subjects: Research > Research Center - Health Sciences
Depositing User: KMC Library
Date Deposited: 06 Mar 2018 03:51
Last Modified: 06 Mar 2018 03:51
URI: http://eprints.manipal.edu/id/eprint/150692

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