Liquisolid Technique Using Tween 80 and Sodium Starch Glycolate to Enhance the Solubility and Dissolution Rate of an Antihypertensive Drug

Kumar, Lalit and Lewis, Shaila (2018) Liquisolid Technique Using Tween 80 and Sodium Starch Glycolate to Enhance the Solubility and Dissolution Rate of an Antihypertensive Drug. Latin American Journal of Pharmacy, 37 (4). pp. 717-726. ISSN 0326 2383

[img] PDF
4332 DisplayPdf.pdf - Published Version
Restricted to Registered users only

Download (897kB) | Request a copy

Abstract

Lacidipine (LCDP), a BCS class II calcium channel blocker, is used as antihypertensive agent. LCDP possesses low aqueous solubility and also undergoes extensive first pass metabolism resulting in oral bioavailability of 10%. The present study was aimed to enhance the solubility and hence dissolution rate of LCDP by formulating into liquisolid compacts. LCDP liquisolid compacts were formulated using avicel PH 102, tween 80, aerosil 200 and sodium starch glycolate. A mathematical model was adopted to determine the suitable quantity of carrier and coating materials. The formulated tablets were evaluated for post compression parameters. Liquisolid tablets showed high drug release as compared to the pure drug. The optimized formulation exhibited 99.89 ± 0.162% of drug release within 45 min. Stability studies confirmed the stability of optimized formulation. Present study thus concluded that the liquisolid is a favourable technique to improve the solubility and drug release of LCDP

Item Type: Article
Uncontrolled Keywords: BCS class II; Dissolution rate; Lacidipine; Liquisolid; Solubility; Stability
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Library
Date Deposited: 26 May 2018 03:57
Last Modified: 26 May 2018 03:57
URI: http://eprints.manipal.edu/id/eprint/151135

Actions (login required)

View Item View Item