Antifungal susceptibility and phenotypic virulence markers of Candida species isolated from Nepal

Bairy, Indira (2017) Antifungal susceptibility and phenotypic virulence markers of Candida species isolated from Nepal. BMC Research Notes, 10 (1). pp. 1-7. ISSN 1756-0500

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Abstract

Objective: Candida species are part of the commensal microflora in many anatomical sites of the human body; however, breach in the integrity of the body part and impaired immunity of the host can lead to invasive candidiasis.A number of irulence determinants could contribute towards its pathogenicity. Thus we attempted to evaluate the in vitro expression of different virulence factors among clinical isolates of Candida species and assayed their susceptibility patterns against a range of antifungal agents.Result: Of the total of 71 isolates we obtained, 48 (67.6%) were Candida albicans, 11 (15.49%) Candida tropicalis,09 (12.67%) Candida glabrata and 03 (4.22%) were Candida krusei. Proteinase, phospholipase and esterase production could be revealed amongst 43 (60.56%), 44 (61.97%) and 49 (69.01%) isolates respectively. None of the isolates showed DNAase activity. Fifty-five (77.39%) isolates were biofilm producers, and 53 (74.6%) exhibited high cell surface hydrophobicity.

Item Type: Article
Uncontrolled Keywords: Candida species; Virulence factors; Antifungal susceptibility testing
Subjects: Medicine > MMMC Manipal > Microbiology
Depositing User: KMC Library
Date Deposited: 26 May 2018 04:04
Last Modified: 26 May 2018 04:04
URI: http://eprints.manipal.edu/id/eprint/151139

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