Mallya, Nandita H and Varashree, BS and Bhatkalkar, Shruti N and Shenoy, Revathi P (2017) Correlation of erythrocyte glutathione peroxidase activity with high levels of HbA1c. Indian Journal of Medical Sciences, 69 (3). pp. 18-20. ISSN 0019-5359

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Abstract

Hyperglycemia induces increased generation of reactive oxygen species and decreased action of antioxidant enzymes which leads to oxidative stress. Antioxidant enzymes prevent the action of reactive oxygen species and protect the cells from oxidative damage. Glutathione peroxidase is one of the antioxidant enzyme. The aim of the study was to evaluate the association between antioxidant enzyme glutathione peroxidase activity in erythrocytes with elevated HbA1c levels. Material and Method: Total of 92 whole blood samples were taken based on their HbA1c levels and were divided control (n=52) and hyperglycaemic group (n=40). Glutathione peroxidase activity in erythrocyte was measured. Statistical difference between groups was analyzed using independent t test. Pearson’s correlation analysis was performed to determine the relationships between variables. Results: There was no significant difference in glutathione peroxidase activity between the groups. There was statistically significant (p <0.001) increase observed for HbA1c and blood glucose in their mean±SD values from control to hyperglycaemic group. There was no significant correlation observed between glutathione peroxidase and HbA1c as well as blood glucose. The results indicate that elevated levels of HbA1c does not alter the activity of erythrocyte glutathione peroxidase activity.

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