Metabolomics in sepsis and its impact on public health

Satyamoorthy, K and Brand, Angela (2017) Metabolomics in sepsis and its impact on public health. Public Health Genomics, 20 (5). pp. 274-285. ISSN 1662-4246

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Sepsis, with its often devastating consequences for patients and their families, remains a major public health concern that poses an increasing financial burden. Early resuscitation together with the elucidation of the biological pathways and pathophysiological mechanisms with the use of “-omics” technologies have started changing the clinical and research landscape in sepsis. Metabolomics (i.e., the study of the metabolome), an “-omics” technology further down in the “-omics” cascade between the genome and the phenome, could be particularly fruitful in sepsis research with the potential to alter the clinical practice. Apart from its benefit for the individual patient, metabolomics has an impact on public health that extends beyond its applications in medicine. In this review, we present recent developments in metabolomics research in sepsis, with a focus on pneumonia, and we discuss the impact of metabolomics on public health, with a focus on free/libre open source software.

Item Type: Article
Uncontrolled Keywords: Commons arrangements ; Free/libre open source software ; Metabolomics ; Public health ; Sepsis.
Subjects: Departments at MU > Public Health
Life Sciences > MLSC Manipal
Depositing User: KMC Library
Date Deposited: 28 May 2018 09:51
Last Modified: 28 May 2018 09:51

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