Genetic variants identified from GWAS for predisposition to type 2 diabetes predict sulfonylurea drug response

Phani, Nagaraja M and Vohra, Manik and Adhikari, Prabha and Shivashankara, KN and Shashikiran, U and Kalluri, PRR and Satyamoorthy, K and Rai, Padmalatha S (2017) Genetic variants identified from GWAS for predisposition to type 2 diabetes predict sulfonylurea drug response. Current Molecular Medicine, 17 (8). pp. 580-586. ISSN 1566-5240

[img] PDF
RMS - 00004387.pdf - Published Version
Restricted to Registered users only

Download (3MB) | Request a copy

Abstract

BACKGROUND:Several SNPs were identified through GWAS for their association with type 2 diabetes which has implications to pancreatic β-cell physiology. OBJECTIVE: We aimed to study the role of risk alleles of TCF7L2, KCNJ11, CDKN2A, CDKAL1, IGF2BP2, SLC30A8 and KCNQ1 along with pharmacokinetic variants in response to sulfonylureas. METHOD: We performed a prospective study on 209 newly diagnosed subjects; treatment naive T2D subjects were recruited. Individuals were started with glibenclamide monotherapy and followed-up for 12 weeks. Genotyping was done, using PCR-RFLP and TETRA-ARMS PCR and confirmed by DNA sequencing. RESULTS: In univariate regression analysis, KCNJ11 (rs5219) was only the predictor for glibenclamide treatment failure. CONCLUSION: The present data suggests a possible role of KCNJ11 gene in altered response to glibenclamide.

Item Type: Article
Uncontrolled Keywords: Genome Wide Association Studies (GWAS); Glibenclamide; KCNJ11 gene.; Sulfonylurea; T-ARMSPCR; Type 2 Diabetes.
Subjects: Life Sciences > MLSC Manipal
Medicine > KMC Mangalore > Medicine
Medicine > KMC Manipal > Medicine
Depositing User: KMC Library
Date Deposited: 29 May 2018 11:15
Last Modified: 29 May 2018 11:15
URI: http://eprints.manipal.edu/id/eprint/151181

Actions (login required)

View Item View Item