Hypoglycemic effect of YXK12 (polyherbal product) in normal rats

*, Rathnakar U.P and *, Hashim S.K and *, Sudhakar Pemminati and Ullal, Sheetal D. and Pai , MRSM, and *, Nandita V and *, Farsana UK and *, Aboobecker S.P.A (2010) Hypoglycemic effect of YXK12 (polyherbal product) in normal rats. Journal of Pharmacy Research, 3 (7). pp. 1517-1518. ISSN 0974-6943

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Abstract

Diabetes mellitus [DM] is a chronic metabolic disorder that continues to present a major world wide health problem. Many herbal products have been used in an attempt to cure or control DM, since ages. Numerous herbal drugs like Momordica charantia, Tinospora cordifolia, Terminalia cattapa, Melia azadirachta and Syzygium cumini have been used by people of various cultures to treat diabetes. YXK12 is a recently introduced, commercially available, polyherbal product being recommended for use in diabetic patients. As no data is available on the safety and efficacy, of this polyherbal combination, the present study was undertaken to study and evaluate the hypoglycemic property of this polyherbal product in normal rats. Hypoglycemic effects of two doses of YXK12 [1000 mg/ kg and 2000 mg/kg] was tested in Wistar rats in two groups of six animals each and the results were statistically compared with the results of Tween 80[vehicle] and Glibenclamide [standard drug], also from two groups of six animals each. Significant hypoglycemic effects [P<001] were observed only in higher dose [2000 mg/kg] in normal rats. The current study has demonstrated hypoglycemic activity only in very high doses in normal rats. This dose [2000 mg/kg in rats] if converted to human dose is equivalent to highest human dose recommended. As lower doses have not demonstrated any hypoglycemic activity, lower doses in humans needs to be evaluated.

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