Localized in situ nanoemulgel drug delivery system of quercetin for periodontitis: Development and computational simulations

Aithal, Gururaj C and Nayak, Usha Yogendra and Mehta, Chetan and Narayan, Reema and Gopalkrishna, Pratibha (2018) Localized in situ nanoemulgel drug delivery system of quercetin for periodontitis: Development and computational simulations. Molecules, 23 (1363). pp. 1-15. ISSN 1420-3049

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Abstract

This study was aimed at formulating a bioabsorbable, controlled-release, nanoemulgel of Quercetin, a potent antimicrobial and anti-inflammatory agent for the treatment of periodontitis that could improve its solubility and bioavailability. Screening of components was carried out based on the solubility studies. Nanoemulsion containing cinnamon oil as the oil phase, tween 80 and Carbitol® as the surfactant-cosurfactant mixture (Smix) and water as the aqueous phase containing 125 �g/200 �L of Quercetin was prepared by using spontaneous emulsification method. Nanoemulgel was prepared using 23% w/v poloxamer 407 as gel base. Comprehensive evaluation of the formulated nanoemulgel was carried out, and the optimized formulation was studied for drug release using Franz vertical diffusion cells. The formulated nanoemulgelexhibited a remarkable release of 92.4% of Quercetin at the end of 6 h, as compared to that of pure Quercetin-loaded gel (<3% release). The viscosity of the prepared nanoemulgel was found to be 30,647 � 0.32 cPs at 37 �C. Also, molecular dynamics (MD) simulation was utilized to understand the gelation process and role of each component in the formulation. The present study revealed that the developed nanoemulgel of Quercetin could be a potential delivery system for clinical testing in periodontitis.

Item Type: Article
Uncontrolled Keywords: Nanoemulgel; periodontitis; spontaneous emulsification; antimicrobial;molecular simulation; computational formulation design.
Subjects: Dentistry > MCODS Manipal > Periodontology
Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Library
Date Deposited: 11 Jun 2018 03:49
Last Modified: 11 Jun 2018 03:49
URI: http://eprints.manipal.edu/id/eprint/151267

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