Progressive Non-familial Adult onset Cerebellar Degeneration: An Unusual Occurrence with Hashimoto’s Thyroiditis

Rao, Raghavendra S and Seshadri, Shubha and Bhattacharjee, Dipanjan and Patil, Navin A and Rao, Karthik (2018) Progressive Non-familial Adult onset Cerebellar Degeneration: An Unusual Occurrence with Hashimoto’s Thyroiditis. Psychopharmacology Bulletin, 48 (2). pp. 1-5.

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Abstract

Progressive non-familial adult onset cerebellar degeneration has been rarely associated with hypothyroidism and is known to be reversible after therapy. We report a case of cerebellar atrophy in a 31 year old female whose detailed evaluation had revealed sub-clinical hypothyroidism secondary to autoimmune thyroiditis with a very high anti- TPO (anti-thyroid peroxidase) antibody levels. MRI (Magnetic Resonanace Imaging) of brain showed diffuse bilateral cerebellar atrophy. She was treated with thyroid hormone supplementation and after one year of follow up, cerebellar signs had disappeared completely with significant reduction in anti-TPO antibody levels. Imaging of the brain post one year of follow-up revealed normal cerebellum. Hence, we opine that thyroid dysfunction should always be kept in mind while evaluating patients presenting with acute onset cerebellar ataxia as it can be easily reversed with thyroid hormone replacement therapy.

Item Type: Article
Uncontrolled Keywords: Cerebellar atrophy; Sub-clinical hypothyroidism; Reversible; Anti-TPO antibodies; Autoimmune thyroiditis
Subjects: Medicine > KMC Manipal > Medicine
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 23 Jun 2018 06:00
Last Modified: 23 Jun 2018 06:00
URI: http://eprints.manipal.edu/id/eprint/151329

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