Development of Polyvinlyl Alcohol-Chitosan Hydroxypropylmethylcellulose Based Composite Films for Controlled Drug Delivery

Saran, Gopalakrishnan and Daththri, Eshwari and Thakur, Goutam and Koteshwara, K B (2018) Development of Polyvinlyl Alcohol-Chitosan Hydroxypropylmethylcellulose Based Composite Films for Controlled Drug Delivery. Trends in Biomaterials and Artificial Organs, 31 (3). pp. 97-101. ISSN 0971-1198

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Abstract

The study aims at developing composite films of polyvinyl alcohol (PVA), chitosan (Cs) and Hydroxypropyl-methylcellulose (HPMC) using the solvent casting method. The films are developed with enhanced mechanical stability to help in reducing inflammation and providing the initial dressing to aid in wound healing. Films of different polymer ratios were developed and optimized for further characterization studies, the optimal blends were then selected for drug diffusion studies with curcumin. Films of HPMC:chitosan:PVA ratios of 1:1:1 and 1:1:2 have showed improved tensile strength (56.77 MPa and 113.76 MPa respectively), showed more sustained swelling for 25 minutes in comparison to other samples. FTIR analysis and SEM analysis indicated interaction among the polymers while its surface morphology being continuous and uniform. Film HPMC:chitosan:PVA ratio of 1:1:1 (HCP1) exhibited substantially efficient release of 16.38±0.126% over 3 hours and found best fit in zero order following non Fickian diffusion. The film characteristics and diffusion studies indicated that the drug-loaded film could hold good for its application in wound healing.

Item Type: Article
Subjects: Engineering > MIT Manipal > Biomedical
Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: MIT Library
Date Deposited: 26 Jun 2018 11:15
Last Modified: 26 Jun 2018 11:15
URI: http://eprints.manipal.edu/id/eprint/151365

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