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Acute Toxicity and Diuretic Studies of the Roots of Asparagus racemosus Willd in Rats

*, MC Satish Kumar and *, AL Udupa and *, K Sammodavardhana and *, UP Rathnakar and *, Udapa Shvetha and *, GP Kodancha (2010) Acute Toxicity and Diuretic Studies of the Roots of Asparagus racemosus Willd in Rats. West Indies medical journal, 59 (1). pp. 3-5.

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Abstract

Objective: Asparagus racemosus Willd has been used as diuretic in Ayurveda but has not been validated by a suitable experimental model. Hence the present study was undertaken. Materials and Methods: The study was carried out with an aqueous extract of the roots of Asparagus racemosus utilizing three doses viz 800 mg/kg, 1600 mg/kg and 3200 mg/kg for its diuretic activity in comparison with standard drug (furosemide) and control (normal saline) rats after doing acute toxicity study. Results: Acute toxicity study showed no fatality even with the highest dose and the diuretic study revealed significant diuretic activity (p < 0.05) in the dose of 3200 mg/kg. Conclusion: Asparagus racemosus showed diuretic activity at a 3200 mg/kg dose without acute toxicity

Item Type: Article
Uncontrolled Keywords: Asparagus racemosus; Toxicity; Diuretic activity
Subjects: Medicine > KMC Mangalore > Pharmacology
Depositing User: KMCMLR User
Date Deposited: 13 Oct 2011 11:03
Last Modified: 18 Oct 2011 06:50
URI: http://eprints.manipal.edu/id/eprint/1516

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