Pharmacotherapy of heart failure

Amberkar, Mohan Babu V and Thanusubramanian, Harish and Kumari, Meena K and Shaik, Arshad Basha (2018) Pharmacotherapy of heart failure. Asian Journal of Pharmaceutical and Clinical Research, 11 (6). pp. 78-87. ISSN 0974-2441

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Abstract

Heart failure (HF) is one of the major problems related to heart diseases in the modern era. Multiple comorbidities such as coronary artery disease, hypertension, diabetes mellitus, and anemia have a great contribution in the development of HF. It is primarily two types systolic and diastolic HF. Insufficient or decreased pumping of the heart is systolic HF, whereas diastolic HF is because of lack of ability of the heart to relax or increased muscle inflexibility. The pathophysiology of HF is due to enhanced activity of sympathetic system, renin angiotensin system, and structural changes in the wall of ventricle. The two definite targets of medical treatment in HF are as follows: (1) Alleviation of obstructive (or) decreased output manifestations and replenishment of cardiac function. The drugs used are frusemide, thiazides, angiotensin-converting enzyme (ACE inhibitors/angiotensin receptor blockers (ARBs), amrinone/milrinone, dopamine/dobutamine, levosimendan, digoxin, hydralazine, nitroprusside, nitrate, bisoprolol, metoprolol, nebivolol, and carvedilol. (2) Prevention of advancement of HF and extension of patient survival - drugs used are β blockers, ACE inhibitors/ARBs, spironolactone, and eplerenone.

Item Type: Article
Uncontrolled Keywords: Digoxin diuretics Angiotensin converting enzyme inhibitors.
Subjects: Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 01 Aug 2018 05:48
Last Modified: 01 Aug 2018 05:48
URI: http://eprints.manipal.edu/id/eprint/151662

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