Preparation and characterization of novel tamarind gum‑based hydrogels for antimicrobial drug delivery applications

Sharma, Vivek and Patnaik, Pallavi and Senthilguru, K and Nayak, Suraj Kumar and Syed, Irshaan and Singh, Vinay K and Sarkar, Preetam and Thakur, Goutam and Pal, Kunal (2018) Preparation and characterization of novel tamarind gum‑based hydrogels for antimicrobial drug delivery applications. Chemical Papers, 72 (8). pp. 2101-2113. ISSN 0366-6352

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Abstract

Tamarind gum (TG) polysaccharide has shown great potential in food and pharmaceutical applications due to their viscositymodulating properties. In this study, TG hydrogels of varied concentrations were developed by physical gelation method. The prepared hydrogels were characterized by microscopy, XRD, FTIR, mechanical, electrical and drug release studies. Microscopic studies showed formation of globular structures throughout the matrix. XRD and FTIR studies suggested an increase in the associative interactions when the TG content was increased, which in turn resulted in the alteration in the mechanical properties. An increase in the intrinsic ionic conductivity was predicted from the electrical studies. This increase in intrinsic ionic conductivity modulated the release of the drug from the hydrogels. The drug was released in its active form. In gist, it can be concluded that the physical hydrogels prepared using TG may be explored as matrices for drug delivery applications

Item Type: Article
Uncontrolled Keywords: Tamarind gum · Hydrogel · Microscopy · Drug delivery · E. coli
Subjects: Engineering > MIT Manipal > Biomedical
Depositing User: MIT Library
Date Deposited: 06 Aug 2018 09:12
Last Modified: 06 Aug 2018 09:12
URI: http://eprints.manipal.edu/id/eprint/151698

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