N-Terminal-pro Brain Natriuretic Peptide in Assessing the Severity of Stable Coronary Artery Disease

Shenoy, Vijetha Belle and Prabhu, Krishnananda RV and Rao, Pragna and Kamath, Asha (2018) N-Terminal-pro Brain Natriuretic Peptide in Assessing the Severity of Stable Coronary Artery Disease. Journal of Clinical and Diagnostic Research, 12 (8). pp. 25-28. ISSN 0973-709X

[img] PDF
4850 DisplayPdf.pdf - Published Version
Restricted to Registered users only

Download (330kB) | Request a copy


Introduction: Coronary Artery Disease (CAD) occurs due to atherosclerosis which results in progressive narrowing of coronary artery lumen. N-Terminal pro Brain Natriuretic Peptide (NT-proBNP) has been used as a marker of heart failure. However, its role in stable coronary artery disease without left ventricular dysfunction is limited.Aim: To measure and compare the serum NT-proBNP levels in stable coronary artery patients and controls and to correlate serum NT-proBNP levels with severity of CAD.Materials and Methods: The present study was conducted in Department of Biochemistry in collaboration with Department of Cardiology Kasturba Medical College, Manipal after the approval from Institutional Ethics Committee. A written consent was obtained from 86 study subjects (controls 36, cases 50).Serum NT-proBNP was measured using ELISA kit. Severity of CAD was graded by angiogram based Gensini scoring system.Mann-Whitney U-tests and spearman’s correlations were used.Serum NT-proBNP was expressed in median and interquartile range. The p- value<0.05 was considered to be significant.Results: Median values of serum NT-proBNP levels in cases(151.9 pg/mL) were significantly higher as compared to that of controls (99.31 pg/mL), (p<0.001). There was a significant positive correlation of serum NT-proBNP with the respective Gensini scores in patients with stable coronary artery disease (r=0.263, p=0.014). Conclusion: As Serum NT-proBNP levels were significantly associated with severity of stable CAD without left ventricular dysfunction, it can be a potential tool in effective management of stable CAD.

Item Type: Article
Uncontrolled Keywords: Enzyme linked immunosorbent assay; Gensini score; Natriuretic peptides
Subjects: Medicine > KMC Manipal > Biochemistry
Departments at MU > Statistics
Depositing User: KMC Library
Date Deposited: 21 Aug 2018 06:16
Last Modified: 21 Aug 2018 06:16
URI: http://eprints.manipal.edu/id/eprint/151790

Actions (login required)

View Item View Item