Effect of Ketamine and Fentanyl in Combination with Midazolam and Propofol during Outpatient Colonoscopy-A Randomised Controlled Trial

Upadya, Madhusudan and *, Neeta S. and Brar, Gagan and Kulkarni, Anand and Chacko, Jose (2018) Effect of Ketamine and Fentanyl in Combination with Midazolam and Propofol during Outpatient Colonoscopy-A Randomised Controlled Trial. Journal of Clinical and Diagnostic Research, 12 (9). UC05-UC09. ISSN 0973-709X

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Abstract

Introduction: There are various methods for sedation in colonoscopies and ketamine has been found to be an effective alternative drug for sedation. Aim: To compare the efficacy and haemodynamic stability of lower dose of ketamine and fentanyl co-administered with midazolam and propofol for colonoscopies. Materials and Methods: Sixty American Society of Anaesthesiologists (ASA) I-II patients undergoing colonoscopies were randomised into 2 groups. Group I (n=30) (Fentanyl group) was assigned to receive midazolam 20μg/kg, propofol and fentanyl 2μg/kg. Group II (n=30) (Ketamine group) was assigned to receive midazolam 20μg/kg, propofol and ketamine 0.5mg/kg. The parameters measured include haemodynamic stability, recovery, pain scores and endoscopists satisfaction. All statistical analysis was carried out using Medcalc Statistical Software version 11.0 (Medcalc Software bvba, Belgium). Results: The time to full sedation in the ketamine group was significantly less than that in the fentanyl group (18.3±2.7 seconds Vs 22.4±2.2 seconds). Patients belonging to the ketamine group had a significantly shorter recovery time compared to those in the fentanyl group (5.8±1.4 Vs 8.0±1.9 minutes). Overall patient satisfaction was significantly higher with the use of ketamine. Patients were haemodynamically more stable with a lower incidence of hypotension in ketamine group. Conclusion: The present study shows that midazolam/ketamine /propofol combination provides adequate levels of analgesia and sedation, quicker recovery and has “propofol sparing” effect.

Item Type: Article
Uncontrolled Keywords: Anaesthesia, Analgesia, Recovery, Sedation
Subjects: Medicine > KMC Mangalore > Anaesthesiology
Depositing User: KMCMLR User
Date Deposited: 03 Sep 2018 04:58
Last Modified: 03 Sep 2018 04:58
URI: http://eprints.manipal.edu/id/eprint/151925

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