In vivo determination of moisturizers efficacy on human skin hydration by confocal raman spectroscopy

Vamshi, Krishna T (2018) In vivo determination of moisturizers efficacy on human skin hydration by confocal raman spectroscopy. AAPS PharmSciTech, 19 (7). pp. 3177-3186. ISSN 1530-9932

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This research work deals with in vivo testing of the efficacy of commercial moisturizer products on the hydration of human skin, as there are various in vitro and ex vivo studies questioning their activity. Confocal Raman spectroscopy was used for this purpose of assessing the efficacy of moisturizers on skin hydration mainly owing to its simple, non-invasive, non-destructive, timesaving, and cost-effective nature. Water content and natural moisturizing factor (NMF) of stratum corneum were analyzed and compared using this method at high wavenumber (2500–4000 cm−1) and fingerprint (400–1800 cm−1) spectral regions, respectively, as these two parameters are correlated to skin hydration. Four commercial moisturizer products of different brands were tested on volar forearm region of healthy human female volunteers. This study was conducted for a period of 30 days with 0, 7, and 30 days as time points of analysis. The results of this study clearly indicate that not all the moisturizer products hydrate the skin to the expected levels, and this extent of skin hydration varies with duration of application of these products.

Item Type: Article
Uncontrolled Keywords: Moisturizer efficacy; in vivo human skin hydration; confocal Raman spectroscopy.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Library
Date Deposited: 17 Oct 2018 03:51
Last Modified: 17 Oct 2018 03:51

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