Evaluation of Potential Drug-Drug Interactions with Medications Prescribed to Geriatric Patients in a Tertiary Care Hospital

Shetty, Varsha and Chowta, Mukta N and Chowta, Nithyananda K and Shenoy, Ashok K and Kamath, Ashwin and Kamath, Priyanka (2018) Evaluation of Potential Drug-Drug Interactions with Medications Prescribed to Geriatric Patients in a Tertiary Care Hospital. Journal of Aging Research, 2018. pp. 1-6. ISSN 20902204

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Abstract

Background and Objectives. +e drugs most commonly implicated in major potential interactions are those used in the day-to-day clinical management of elderly patients with chronic diseases. +is study is planned to evaluate the profile of drug-drug interactions in the medications prescribed to elderly population and also to identify the possible predictors for potential drug-drug interactions in the elderly. Methods. +is cross-sectional study included patients aged above 60 years with a minimum of two drugs in the prescriptions. Data were collected from medical prescriptions and patients’ medical records. +e data collected included demographic characteristics such as age, gender, height, weight, educational status, socioeconomic status, medical history, and medications prescribed. +e prescriptions were analyzed for the potential drug interactions using Lexi-Interact™ Online, an online software to check drug-drug interactions. Results. A total of 209 patients were included in the study, among them 104 (49.8%) were males and 105 (50.2%) were females. +e mean number of medications received was 6.53 ± 2.15 per prescription. Around 138 (66%) patients received more than six medications. +e mean number of potential drug interactions seen in the prescription of these patients was 3.17 ± 2.78. Around 18.2% patients had more than five drug interactions. Major drug interactions were observed in 21.42% of cases. Around 3.02% of drug interactions belonged to risk category X, i.e., to be avoided. Logistic regression analysis showed that age above 70 years was associated with the presence of drug interactions. Increased number of medication was independently associated with the occurrence of drug interactions. +e presence of drug interactions was not associated with increased number of comorbidities. Conclusion. A significant number of potential drug-drug interactions were seen in the prescriptions of elderly patients. Increasing age and polypharmacy were identified as the predictors of potential drug interactions.

Item Type: Article
Uncontrolled Keywords: Drug interactions, Elderly, Prescriptions
Subjects: Medicine > KMC Mangalore > Pharmacology
Medicine > KMC Mangalore > Medicine
Depositing User: KMCMLR User
Date Deposited: 17 Oct 2018 04:46
Last Modified: 17 Oct 2018 04:46
URI: http://eprints.manipal.edu/id/eprint/152158

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