Vitamin D Levels in Late Pre-Term Neonates and its Association with Sepsis

Prasad, Rahul and Baliga, Shantharama B and Baliga, Kiran N and D'Sa, Smitha Sharlette (2018) Vitamin D Levels in Late Pre-Term Neonates and its Association with Sepsis. Indian Journal of Public Health Research and Development, 9 (10). pp. 128-132. ISSN 09760245

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Abstract

Vitamin D deficiency is a major health concern & prevalence rates in preterm neonates is still not well defined. Role of Vitamin D deficiency in critically ill patients with sepsis has been reported in the adult population. This study aims at studying Vitamin D levels in late preterm neonates and its association with sepsis. Objectives : To estimate & identify Vitamin D deficiency in late Pre-termers, in turn studying their levels in late onset sepsis and estimating the change in Vitamin D levels with the onset of sepsis. Methodology: A total of 120 late pre-termers were included in the study. Gestation age calculated by New Ballard’s score. Structured pro-forma recorded birth details. Baseline vitamin D levels of all babies were obtained on day 4).Those 67 neonates with features of late onset sepsis either clinically/haematological/ culture were sub-grouped as cases & remaining 53 were controls. Subsequent vitamin D level was estimated in septic cases after 48 hours of onset Results: Mean value of vitamin D on day 4 was 18.9 indicating vitamin D deficiency (p<0.001). There was no difference in baseline vitamin D levels in those who developed sepsis and those who did not. Amongst cases, mean value of Vitamin D before onset of sepsis was 26.27ng/ml and 19.29ng/ml after 48 hours of onset; indicating a highly significant drop in vitamin D within 48 hours of onset of sepsis(p<0.001).There was no significant association between culture proven sepsis & vitamin D deficiency. Vitamin D deficiency does not predispose to sepsis. Conclusions: There is need to establish normal Vitamin D levels in our population. There is no evidence in this study to say Vitamin D deficiency predisposes to sepsis. However there is significant drop in vitamin D levels with onset of sepsis.

Item Type: Article
Uncontrolled Keywords: Vitamin D, Late Preterm neonates, Late onset sepsis.
Subjects: Medicine > KMC Mangalore > Paediatrics
Depositing User: KMCMLR User
Date Deposited: 10 Nov 2018 06:12
Last Modified: 10 Nov 2018 06:12
URI: http://eprints.manipal.edu/id/eprint/152232

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