Kabekkodu, Shama Prasada and Shukla, Vaibhav and Varghese, Vinay Koshy and D’ Souza, Jeevitha and Chakrabarty, Sanjiban and Satyamoorthy, K (2018) Clustered miRNAs and their role in biological functions and diseases. Biological Reviews, 93. pp. 1955-1986.
![]() |
PDF
5303 DisplayPdf.pdf - Published Version Restricted to Registered users only Download (1MB) | Request a copy |
Abstract
MicroRNAs (miRNAs) are endogenous, small non-coding RNAs known to regulate expression of protein-coding genes.A large proportion of miRNAs are highly conserved, localized as clusters in the genome, transcribed together from physically adjacent miRNAs and show similar expression profiles. Since a single miRNA can target multiple genes and miRNA clusters contain multiple miRNAs, it is important to understand their regulation, effects and various biological functions. Like protein-coding genes, miRNA clusters are also regulated by genetic and epigenetic events. These clusters can potentially regulate every aspect of cellular function including growth, proliferation, differentiation, development, metabolism, infection, immunity, cell death, organellar biogenesis, messenger signalling, DNA repair and self-renewal, among others. Dysregulation of miRNA clusters leading to altered biological functions is key to the pathogenesis of many diseases including carcinogenesis. Here, we review recent advances in miRNA cluster research and discuss their regulation and biological functions in pathological conditions.
Item Type: | Article |
---|---|
Uncontrolled Keywords: | MiRNA cluster; Epigenetics; Genetics; Metabolism; Immunity; Cancer |
Subjects: | Life Sciences > MLSC Manipal |
Depositing User: | KMC Library |
Date Deposited: | 15 Nov 2018 11:14 |
Last Modified: | 15 Nov 2018 11:14 |
URI: | http://eprints.manipal.edu/id/eprint/152311 |
Actions (login required)
![]() |
View Item |