Development of Fluconazole Suppositories for the Treatment of Candida Infection of Genitourinary Tract

Reddy, Saketh R and Kumar, Lalit and Pydi, Chinna Raja and Reddy, Sreenivasa M and Verma, Ruchi (2018) Development of Fluconazole Suppositories for the Treatment of Candida Infection of Genitourinary Tract. Indian Journal of Pharmaceutical Education and Research, 52 (4). pp. 16-22. ISSN 0019-5464

[img] PDF
5373 DisplayPdf.pdf - Published Version
Restricted to Registered users only

Download (929kB) | Request a copy


Background: Vulvovaginal candidiasis is a communal problem in virtually all the women which is caused by Candida albicans. Objective: Aim of the present study was to prepare and characterize vaginal suppositories of fluconazole for the treatment of vulvovaginal candidiasis. Methods: Fluconazole suppositories were prepared using water soluble and fatty bases. Bases and their proportions used were selected in such a way that they have flexibility in storage conditions unlike conventional suppositories. Suppositories were prepared and examined for physical characteristics and in vitro release studies. Results: Present study showed ultimate results with respect to the physical characteristics of suppositories and in vitro drug release studies. In vitro drug release from the prepared suppositories was in the following order FVS 3 (100.00 ± 3.7% in 1.0 h) > FVS 1 (86.29 ± 4.9% in 12.0 h) > FVS 2 (80.47 ± 2.4% in 12.0 h) > FVS 5 (22.51 ± 0.42% in 24.0 h) > FVS 4 (18.09 ± 1.31% in 24.0 h). These drug release results are supported by the disintegration time of suppositories. Lesser the disintegration time faster the drug release. Conclusion: Study concludes that it may be fruitful to explore the in vivo activities of suppositories prepared with the combination of agar and HPMC as it showed around 80% drug release over 12.0 h. Represented combination may also be more effective for the treatment of vulvovaginal candidiasis.

Item Type: Article
Uncontrolled Keywords: Vulvovaginal candidiasis; Candida albicans; Fluconazole; Fluconazole suppositories; Vaginal suppositories; Vaginal infection; Agar; Hydroxypropyl methylcellulose; Glycerol-gelatin; Cocoa butter; Bees wax
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Library
Date Deposited: 22 Nov 2018 09:45
Last Modified: 22 Nov 2018 09:45

Actions (login required)

View Item View Item