Nanocrystals: A newer technological advancement in drug delivery

Xalxo, Neha and Naha, Anup and Dhoot, Abhishek Sunil and Priya, Juhi (2018) Nanocrystals: A newer technological advancement in drug delivery. Research Journal of Pharmacy and Technology, 11 (4). pp. 1685-1690. ISSN 0974-3618

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Abstract

Solubility is defined as dissolution of a solute in a solvent to give a homogenous system. It is an important consideration which is required to achieve appropriate drug concentration in systemic circulation for a chosen pharmacological response. With innovation in technologies, the discoveries of drugs having better efficacy are restricted due to poor solubility, despite having clinical efficacy. Hence it has become a major challenge. More than 50% new chemical entities produced in pharmacy industry are practically insoluble in water. Nano crystals have potential to overcome this issue. They have size in nanometer range (mean diameter < 1000nm) which changes the drug properties dramatically. This review article summaries different methods of preparation, various production technologies available currently in industries; evaluation techniques, applications of nano crystal formulation, future trends and challenges of nano crystal formulation, and various marketed dosage forms developed using nano crystals are discussed.

Item Type: Article
Uncontrolled Keywords: Nanocrystal; Solubility; Bioavailability; Drug Delivery.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Library
Date Deposited: 30 Nov 2018 08:53
Last Modified: 30 Nov 2018 08:53
URI: http://eprints.manipal.edu/id/eprint/152356

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