Efficacy of ormeloxifene in management of dysfunctional uterine bleeding

Sawarkar, Umesh and Deshmukh, Sarang and Raut, Ashwini and Bhosale, Uma and Shenoy, Ashok K (2018) Efficacy of ormeloxifene in management of dysfunctional uterine bleeding. Asian Journal of Pharmaceutical and Clinical Research, 11 (11). pp. 195-197. ISSN 0974-2441

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Abstract

Objective: The objective was to evaluate the efficacy of ormeloxifene in dysfunctional uterine bleeding (DUB) with respect to bleeding pattern and improvement in hemoglobin (Hb). Methods: This was an interventional study on 99 patients of DUB visiting the gynecology outpatient department over 1 year using semi-structured pro forma. After voluntary participation of patients, tablet ormeloxifene was given at the dose of 30 mg biweekly for 2 months. In case of a therapeutic response as informed by the patient, the dose was reduced to 30 mg weekly for a further period of 4 months. All patients were treated for 6 months. Type, amount, and duration of bleeding, frequency of menstrual cycle, passage of clots, and impact on Hb were assessed. Result and Observations: Menorrhagia was the main type of bleeding. 36–40 years of age group was the most common. After the intervention, 76.8% of women achieved a duration of bleeding of 4–5 days, and in 87% of women, menstrual cycle became regular. Passage of clots was reduced by 71.83%. Mean Hb concentration of study participants increased by 0.5 g/dl at the end of the study. Conclusion: Ormeloxifene is effective alternative and appears to be a promising option for the medical management of DUB

Item Type: Article
Uncontrolled Keywords: Dysfunctional uterine bleeding, Ormeloxifene, Hemoglobin, Menorrhagia, Selective estrogen receptor modulators.
Subjects: Medicine > KMC Mangalore > Pharmacology
Depositing User: KMCMLR User
Date Deposited: 04 Dec 2018 10:54
Last Modified: 04 Dec 2018 10:54
URI: http://eprints.manipal.edu/id/eprint/152396

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