Protective Effect Of Kadukkai Maathirai (Terminalia Chebula-Based Polyherbal Siddha Formulation) In Ethanol-Induced Liver Disease In Rats

Shetty, Manjunath S and Shenoy, Smita and Devi, Vasudha and Kumar, Nitesh and Amuthan, Arul and Shenoy, Ganesh K and Pavithra, P (2018) Protective Effect Of Kadukkai Maathirai (Terminalia Chebula-Based Polyherbal Siddha Formulation) In Ethanol-Induced Liver Disease In Rats. Asian Journal of Pharmaceutical and Clinical Research, 11 (11). pp. 368-371. ISSN 0974-2441

[img] PDF
5451 DisplayPdf.pdf - Published Version
Restricted to Registered users only

Download (814kB) | Request a copy

Abstract

Objective: The objective of this study was to evaluate the prophylactic effect of Kadukkai maathirai (KM) against ethanol-induced hepatotoxicity in rats.Methods: Four groups (n=6) of adult female Sprague–Dawley rats were used. Ethanol was administered in the dose of 45% v/v 15 mL/kg/body weight twice a day for 8 weeks in the study. The four groups were treated orally for 8 weeks with 2% gum acacia (control), ethanol (toxic control),ethanol + KM 72 mg/kg, and ethanol + KM 400 mg/kg, respectively. At the end of 8 weeks, blood was collected by a retro-orbital puncture for the estimation of liver enzymes (aspartate aminotransferase [AST] and alanine aminotransferase [ALT]). The liver was dissected out for histopathology.Using one-way ANOVA and post hoc Tukey’s test, the data were analyzed.Results: There was a significant (p<0.05) decrease in the serum AST and ALT level in rats treated with KM 72 mg/kg as compared to toxic control.Liver parenchyma showed near normal architecture in KM 72 mg/kg-treated group as compared to ethanol- reated group which showed extensive ballooning degeneration of hepatocytes and microvesicular steatosis.Conclusion: KM, in the dose of 2 mg/kg, which is the therapeutic dosage described in Siddha additional literature, exerted hepatoprotective effect against ethanol-induced liver damage in rat.

Item Type: Article
Uncontrolled Keywords: Kadukkai maathirai; Hepatoprotective effect; Microvesicular steatosis; Liver enzymes; Siddha
Subjects: Medicine > MMMC Manipal > Pathology
Medicine > MMMC Manipal > Pharmacology
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 08 Dec 2018 09:13
Last Modified: 08 Dec 2018 09:13
URI: http://eprints.manipal.edu/id/eprint/152433

Actions (login required)

View Item View Item