Analgesic Activity of Pandanus fascicularis Lam

*, Udupa AL and *, Nkemcho Ojeh and Gupta, Subir and *, Ratnakar U P and *, Vijayalakshmi and Rajput, Ravindrasingh and rajput, Amruta and *, Shubha HV and Benegal, Deepa and Benegal, Adarsh and Rao, Sahana and Rao, Sanjana and *, Nisarga S (2010) Analgesic Activity of Pandanus fascicularis Lam. Pharmacologyonline, 2. pp. 837-840.

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Abstract

Pandanus fascicularis Lam has been used in rheumatic fever, rheumatism and rheumatoid arthritis in traditional medicine. There is no scientific study report available on the analgesic action of this plant. The present study is aimed at evaluating the analgesic activity of aqueous extract of Pandanus fasicularis (PF) in rodents. Analgesic activity of the aqueous extract of PF (400 mg/kg and 800mg/kg) was investigated in hotplate models, tail-flick method in rats and the writhing model of mouse and compared with the analgesic action of codeine and aspirin. Aqueous extract of PF revealed significant analgesic activity by both central (p<0.001) and peripheral (p<0.001) mechanisms in this study. These results suggest that the aqueous extracts of PF possess analgesic activity which is comparable to that of codeine and aspirin and this favours the use of PF in rheumatism and rheumatoid arthritis in traditional medicine

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