Management of ventilator-associated pneumonia: Need for a personalized approach

Vandana, KE (2018) Management of ventilator-associated pneumonia: Need for a personalized approach. Expert Review of Anti-infective Therapy, 16 (8). pp. 641-653. ISSN 1478-7210

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Abstract

Introduction: Optimizing management of ventilator-associated pneumonia (VAP) should focus on the accurate identification of true lung infection, determination of the etiological agent, and early institution of adequate empirical therapy and de-escalation. Local adaptation of the standard guidelines leads to favorable outcome in the management of VAP Areas covered: In this review, we present the concepts of early adequate therapy and the key considerations such as patient characters, clinical and etiological diagnosis, and assessment of patients for de-escalation that favor optimization of therapy. We highlight the issues that need a personalized approach in the management of VAP emphasizing on various patient categories for reassessment and tailoring the therapy. Expert commentary: Rapid diagnostic techniques and non-invasive metabolomics will identify phenotypes which will shift the traditional paradigm based on conventional cultures. A personalized approach taking into account baseline resistance epidemiology, underlying disease (and comorbidities), duration of hospitalization, and prior antimicrobial exposure should guide targeted therapy.

Item Type: Article
Uncontrolled Keywords: Adequate therapy; assessment; personalized; pneumonia; ventilator.
Subjects: Medicine > KMC Manipal > Microbiology
Depositing User: KMC Library
Date Deposited: 03 Jan 2019 09:15
Last Modified: 03 Jan 2019 09:15
URI: http://eprints.manipal.edu/id/eprint/152629

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