Hemosiderin Tubulopathy-Induced Acute Kidney Injury - A Rare Initial Manifestation of Paroxysmal Nocturnal Hemoglobinuria

Rao, Srikanth Prasad and Koulmane, Sindhura LL and Nagaraju, Shankar Prasad and Prabhu, Ravindra A and Manohar, Chethan (2018) Hemosiderin Tubulopathy-Induced Acute Kidney Injury - A Rare Initial Manifestation of Paroxysmal Nocturnal Hemoglobinuria. Saudi Journal of Kidney Diseases and Transplantation, 29 (5). pp. 1232-1236. ISSN 1319-2442

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Abstract

Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by episodes of intravascular hemolysis, infections, and thromboembolic complications. Renal abnormalities are rare which occur either due to hemolytic crisis or repeated thrombotic episodes involving small venules. Acute kidney injury (AKI) requiring hemodialysis due to toxic effects of hemoglobinuria, with a stable disease is exceptional. We describe a case of an elderly gentleman presenting with features of severe AKI requiring hemodialysis due to hemosiderin tubulotoxicity as the first manifestation of PNH. The diagnosis was challenging because of the rarity and unfamiliarity with this entity. The outcome was complete recovery of renal function with hemodialysis.

Item Type: Article
Subjects: Medicine > KMC Manipal > Nephrology
Medicine > KMC Manipal > Pathology
Depositing User: KMC Library
Date Deposited: 09 Jan 2019 10:51
Last Modified: 09 Jan 2019 10:51
URI: http://eprints.manipal.edu/id/eprint/152800

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