Role of shear wave elastography in the assessment of fibrosis in chronic liver disease

Bellamkonda, Sravya and Paruthikunnan, Samir Mustaffa and Rajagopal, KV and Sripathi, Smiti (2018) Role of shear wave elastography in the assessment of fibrosis in chronic liver disease. Journal of Diagnostic Medical Sonography, 34 (6). pp. 460-465. ISSN 8756-4793

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Abstract

Objective: To evaluate the diagnostic performance of shear wave elastography in the estimation of fibrosis in patients with chronic liver disease by using biopsy and/or serum markers as reference standard. Materials and methods: 100 patients underwent point quantification-shear wave elastography, for whom noninvasive serum fibrosis indices like APRI, FIB-4, and King’s score were calculated. The receiver-operator characteristic (ROC) curve analysis was performed. Results: The shear wave elastography measurements showed moderate agreement with APRI, FIB-4, and fair agreement with King’s score. The AUROC for differentiating F0-F1, F2-F3, F2-F3, and F4 are 0.873 and 0.504 respectively using APRI as reference standard. The cutoff values derived for differentiating F0-F1 and F2-F3 was 7.07 and for differentiating F2-F3 and F4 was 11.94. Conclusion: The diagnostic performance of shear wave elastography is comparable with that of serum fibrosis indices APRI and FIB-4.

Item Type: Article
Uncontrolled Keywords: Shear wave elastography; chronic liver disease; liver stiffness.
Subjects: Medicine > KMC Manipal > Radiology
Depositing User: KMC Library
Date Deposited: 10 Jan 2019 04:53
Last Modified: 10 Jan 2019 04:53
URI: http://eprints.manipal.edu/id/eprint/152840

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